GO_ID LEVEL(S) TERM NB_IN_REF FREQ_IN_REF NB_IN_SET FREQ_IN_SET P_VALUE ENRICHMENT/DEPLETION GENES_IN_SET GO:0007582 2 physiological process 4771 0.7392 82 0.9011 6.982139E-05 E HOP2,MET16,CYT1,RAT1,AAD6,WAR1,PFS1,MPE1,MON1,MYO1,FZF1,SPO22,PRP8,PDR12,DSK2,SLA2,SPS22,DIA4,MET2,PPT2,MSH5,SPS19,HXT4,MNT4,FIG2,COG6,MTG1,FZO1,NAM9,TOM1,PRM3,SYF2,UNG1,HOS1,HEM4,DCI1,ATP11,IMP2,NAT3,ALP1,CHL1,PNT1,DBF4,TEX1,ATS1,SKI3,REV1,NCR1,MIP6,UBC12,SRB2,EHD3,MRPL44,MSE1,TOS3,PRP16,GAT4,DBP6,PPA2,NHA1,YAP3,TFC7,RHB1,APC11,SPO7,DCN1,OSW2,REC8,SIR3,PAC2,RAD61,HOL1,PRM9,APL6,MTF1,CSM4,DAD2,SSP1,HKR1,FSH3,CBP3,RPI1 GO:0050875 3 cellular physiological process 4641 0.7191 80 0.8791 0.0001313 E HOP2,MET16,CYT1,RAT1,AAD6,PFS1,MPE1,MON1,MYO1,FZF1,SPO22,PRP8,PDR12,DSK2,SLA2,SPS22,DIA4,MET2,PPT2,MSH5,SPS19,HXT4,MNT4,FIG2,COG6,MTG1,FZO1,NAM9,TOM1,PRM3,SYF2,UNG1,HOS1,HEM4,DCI1,ATP11,IMP2,NAT3,ALP1,CHL1,PNT1,DBF4,TEX1,ATS1,SKI3,REV1,NCR1,MIP6,UBC12,SRB2,EHD3,MRPL44,MSE1,TOS3,PRP16,GAT4,DBP6,PPA2,NHA1,YAP3,TFC7,RHB1,APC11,SPO7,DCN1,OSW2,REC8,SIR3,PAC2,HOL1,PRM9,APL6,MTF1,CSM4,DAD2,SSP1,HKR1,FSH3,CBP3,RPI1 GO:0009987 2 cellular process 4682 0.7254 80 0.8791 0.0002074 E HOP2,MET16,CYT1,RAT1,AAD6,PFS1,MPE1,MON1,MYO1,FZF1,SPO22,PRP8,PDR12,DSK2,SLA2,SPS22,DIA4,MET2,PPT2,MSH5,SPS19,HXT4,MNT4,FIG2,COG6,MTG1,FZO1,NAM9,TOM1,PRM3,SYF2,UNG1,HOS1,HEM4,DCI1,ATP11,IMP2,NAT3,ALP1,CHL1,PNT1,DBF4,TEX1,ATS1,SKI3,REV1,NCR1,MIP6,UBC12,SRB2,EHD3,MRPL44,MSE1,TOS3,PRP16,GAT4,DBP6,PPA2,NHA1,YAP3,TFC7,RHB1,APC11,SPO7,DCN1,OSW2,REC8,SIR3,PAC2,HOL1,PRM9,APL6,MTF1,CSM4,DAD2,SSP1,HKR1,FSH3,CBP3,RPI1 GO:0048622 5 reproductive sporulation 92 0.0143 6 0.0659 0.0015045 E PFS1,SPS22,SPS19,SPO7,OSW2,SSP1 GO:0030437 6 sporulation (sensu Fungi) 92 0.0143 6 0.0659 0.0015045 E PFS1,SPS22,SPS19,SPO7,OSW2,SSP1 GO:0045116 8 protein neddylation 5 0.0008 2 0.0220 0.0018862 E UBC12,DCN1 GO:0030476 7,6 spore wall assembly (sensu Fungi) 39 0.0060 4 0.0440 0.0018898 E PFS1,SPS22,OSW2,SSP1 GO:0042244 5 spore wall assembly 39 0.0060 4 0.0440 0.0018898 E PFS1,SPS22,OSW2,SSP1 GO:0000003 2 reproduction 255 0.0395 10 0.1099 0.0021295 E PFS1,MYO1,SLA2,SPS22,SPS19,FIG2,ATS1,SPO7,OSW2,SSP1 GO:0000279 5 M phase 257 0.0398 10 0.1099 0.0022459 E HOP2,SPO22,MSH5,TOM1,CHL1,APC11,SPO7,REC8,CSM4,DAD2 GO:0030435 4 sporulation 105 0.0163 6 0.0659 0.0028504 E PFS1,SPS22,SPS19,SPO7,OSW2,SSP1 GO:0030154 3 cell differentiation 107 0.0166 6 0.0659 0.0031157 E PFS1,SPS22,SPS19,SPO7,OSW2,SSP1 GO:0006635 8,9 fatty acid beta-oxidation 9 0.0014 2 0.0220 0.0064232 E DCI1,EHD3 GO:0015802 7,8,9 basic amino acid transport 9 0.0014 2 0.0220 0.0064232 E ALP1,RHB1 GO:0051327 6 M phase of meiotic cell cycle 129 0.0200 6 0.0659 0.0072859 E HOP2,SPO22,MSH5,SPO7,REC8,CSM4 GO:0007126 7 meiosis 129 0.0200 6 0.0659 0.0072859 E HOP2,SPO22,MSH5,SPO7,REC8,CSM4 GO:0051321 5 meiotic cell cycle 129 0.0200 6 0.0659 0.0072859 E HOP2,SPO22,MSH5,SPO7,REC8,CSM4 GO:0007275 2 development 373 0.0578 11 0.1209 0.0093970 E PFS1,MYO1,SLA2,SPS22,SPS19,FIG2,SPO7,OSW2,SIR3,SSP1,HKR1 GO:0019395 7,8 fatty acid oxidation 11 0.0017 2 0.0220 0.0095440 E DCI1,EHD3 GO:0048610 4 reproductive cellular physiological process 192 0.0297 7 0.0769 0.0127847 E PFS1,SPS22,SPS19,FIG2,SPO7,OSW2,SSP1 GO:0050876 3 reproductive physiological process 192 0.0297 7 0.0769 0.0127847 E PFS1,SPS22,SPS19,FIG2,SPO7,OSW2,SSP1 GO:0007049 4 cell cycle 397 0.0615 11 0.1209 0.0136941 E HOP2,SPO22,MSH5,TOM1,SYF2,CHL1,APC11,SPO7,REC8,CSM4,DAD2 GO:0015809 8,9,10 L-arginine transport 1 0.0002 1 0.0110 0.0140998 E RHB1 GO:0015819 8,9,10 L-lysine transport 1 0.0002 1 0.0110 0.0140998 E RHB1 GO:0046395 7 carboxylic acid catabolism 1 0.0002 1 0.0110 0.0140998 E SPS19 GO:0001101 6 response to acid 1 0.0002 1 0.0110 0.0140998 E WAR1 GO:0016054 6 organic acid catabolism 1 0.0002 1 0.0110 0.0140998 E SPS19 GO:0009062 7,8 fatty acid catabolism 1 0.0002 1 0.0110 0.0140998 E SPS19 GO:0019752 6 carboxylic acid metabolism 300 0.0465 9 0.0989 0.0156166 E MET16,PDR12,DIA4,MET2,SPS19,DCI1,EHD3,MSE1,FSH3 GO:0006082 5 organic acid metabolism 300 0.0465 9 0.0989 0.0156166 E MET16,PDR12,DIA4,MET2,SPS19,DCI1,EHD3,MSE1,FSH3 GO:0006631 6,7 fatty acid metabolism 43 0.0067 3 0.0330 0.0192932 E SPS19,DCI1,EHD3 GO:0016043 4 cell organization and biogenesis 1473 0.2282 28 0.3077 0.0194755 E RAT1,MON1,MYO1,DSK2,SLA2,SPS22,FIG2,COG6,MTG1,FZO1,TOM1,PRM3,HOS1,IMP2,NAT3,PNT1,TEX1,ATS1,MIP6,DBP6,APC11,SPO7,SIR3,PAC2,PRM9,APL6,DAD2,HKR1 GO:0048284 6 organelle fusion 17 0.0026 2 0.0220 0.0217093 E FZO1,PRM3 GO:0000226 8 microtubule cytoskeleton organization and biogenesis 85 0.0132 4 0.0440 0.0247682 E ATS1,APC11,PAC2,DAD2 GO:0006997 6 nuclear organization and biogenesis 49 0.0076 3 0.0330 0.0265100 E TOM1,PRM3,SPO7 GO:0000209 10 protein polyubiquitination 19 0.0029 2 0.0220 0.0265466 E TOM1,UBC12 GO:0000316 8,9 sulfite transport 2 0.0003 1 0.0110 0.0278063 E FZF1 GO:0007024 11,9 alpha-tubulin folding 2 0.0003 1 0.0110 0.0278063 E PAC2 GO:0046655 7,9,8 folic acid metabolism 2 0.0003 1 0.0110 0.0278063 E FSH3 GO:0042558 6 pteridine and derivative metabolism 2 0.0003 1 0.0110 0.0278063 E FSH3 GO:0009314 5 response to radiation 2 0.0003 1 0.0110 0.0278063 E RAD61 GO:0006434 10,11,9 seryl-tRNA aminoacylation 2 0.0003 1 0.0110 0.0278063 E DIA4 GO:0000358 11,12,13,14 formation of catalytic U2-type spliceosome for second transesterification step 2 0.0003 1 0.0110 0.0278063 E PRP16 GO:0006424 10,11,9 glutamyl-tRNA aminoacylation 2 0.0003 1 0.0110 0.0278063 E MSE1 GO:0015849 5,6 organic acid transport 51 0.0079 3 0.0330 0.0291469 E PDR12,ALP1,RHB1 GO:0016567 9 protein ubiquitination 51 0.0079 3 0.0330 0.0291469 E TOM1,UBC12,APC11 GO:0006996 5 organelle organization and biogenesis 1017 0.1576 20 0.2198 0.0297522 E RAT1,MYO1,DSK2,SLA2,MTG1,FZO1,TOM1,PRM3,HOS1,NAT3,PNT1,ATS1,DBP6,APC11,SPO7,SIR3,PAC2,PRM9,DAD2,HKR1 GO:0007010 6 cytoskeleton organization and biogenesis 290 0.0449 8 0.0879 0.0306487 E MYO1,SLA2,NAT3,ATS1,APC11,PAC2,DAD2,HKR1 GO:0006513 10 protein monoubiquitination 22 0.0034 2 0.0220 0.0343936 E TOM1,UBC12 GO:0006555 8,9,7 methionine metabolism 23 0.0036 2 0.0220 0.0371479 E MET16,MET2 GO:0007017 7 microtubule-based process 100 0.0155 4 0.0440 0.0390156 E ATS1,APC11,PAC2,DAD2 GO:0006461 7 protein complex assembly 148 0.0229 5 0.0549 0.0395868 E MTG1,ATP11,DBP6,SSP1,CBP3 GO:0051340 4 regulation of ligase activity 3 0.0005 1 0.0110 0.0411276 E DCN1 GO:0051438 5 regulation of ubiquitin ligase activity 3 0.0005 1 0.0110 0.0411276 E DCN1 GO:0051351 5 positive regulation of ligase activity 3 0.0005 1 0.0110 0.0411276 E DCN1 GO:0051443 6 positive regulation of ubiquitin ligase activity 3 0.0005 1 0.0110 0.0411276 E DCN1 GO:0018206 9 peptidyl-methionine modification 3 0.0005 1 0.0110 0.0411276 E NAT3 GO:0017196 12,10 N-terminal peptidyl-methionine acetylation 3 0.0005 1 0.0110 0.0411276 E NAT3 GO:0006390 8 transcription from mitochondrial promoter 3 0.0005 1 0.0110 0.0411276 E MTF1 GO:0006464 7 protein modification 431 0.0668 10 0.1099 0.0416563 E PPT2,MNT4,TOM1,HOS1,IMP2,NAT3,DBF4,UBC12,APC11,DCN1 GO:0007059 4 chromosome segregation 104 0.0161 4 0.0440 0.0432954 E CHL1,APC11,REC8,CSM4 GO:0000282 7,9,10,8 bud site selection 65 0.0101 3 0.0330 0.0503573 E MYO1,SLA2,HKR1 GO:0007105 6 cytokinesis, site selection 65 0.0101 3 0.0330 0.0503573 E MYO1,SLA2,HKR1 GO:0007062 5 sister chromatid cohesion 28 0.0043 2 0.0220 0.0517648 E CHL1,REC8 GO:0006075 10,9,11,8 beta-1,3 glucan biosynthesis 4 0.0006 1 0.0110 0.0540717 E HKR1 GO:0000350 11,13 formation of catalytic spliceosome for second transesterification step 4 0.0006 1 0.0110 0.0540717 E PRP16 GO:0008053 7 mitochondrial fusion 4 0.0006 1 0.0110 0.0540717 E FZO1 GO:0018065 8 protein-cofactor linkage 4 0.0006 1 0.0110 0.0540717 E PPT2 GO:0006074 9,10 beta-1,3 glucan metabolism 4 0.0006 1 0.0110 0.0540717 E HKR1 GO:0007023 11,9 post-chaperonin tubulin folding pathway 4 0.0006 1 0.0110 0.0540717 E PAC2 GO:0000755 7,5 cytogamy 4 0.0006 1 0.0110 0.0540717 E FIG2 GO:0044237 4 cellular metabolism 3376 0.5231 52 0.5714 0.0549692 E MET16,CYT1,RAT1,AAD6,MPE1,FZF1,PRP8,PDR12,DSK2,DIA4,MET2,PPT2,MSH5,SPS19,MNT4,MTG1,NAM9,TOM1,SYF2,UNG1,HOS1,HEM4,DCI1,ATP11,IMP2,NAT3,DBF4,SKI3,REV1,NCR1,UBC12,SRB2,EHD3,MRPL44,MSE1,TOS3,PRP16,GAT4,DBP6,PPA2,YAP3,TFC7,APC11,DCN1,SIR3,PAC2,MTF1,SSP1,HKR1,FSH3,CBP3,RPI1 GO:0006512 8 ubiquitin cycle 69 0.0107 3 0.0330 0.0571428 E TOM1,UBC12,APC11 GO:0006418 9,10,8 tRNA aminoacylation for protein translation 30 0.0046 2 0.0220 0.0579319 E DIA4,MSE1 GO:0043039 8,9 tRNA aminoacylation 30 0.0046 2 0.0220 0.0579319 E DIA4,MSE1 GO:0043038 7,8 amino acid activation 30 0.0046 2 0.0220 0.0579319 E DIA4,MSE1 GO:0008152 3 metabolism 3427 0.5310 52 0.5714 0.0625926 E MET16,CYT1,RAT1,AAD6,MPE1,FZF1,PRP8,PDR12,DSK2,DIA4,MET2,PPT2,MSH5,SPS19,MNT4,MTG1,NAM9,TOM1,SYF2,UNG1,HOS1,HEM4,DCI1,ATP11,IMP2,NAT3,DBF4,SKI3,REV1,NCR1,UBC12,SRB2,EHD3,MRPL44,MSE1,TOS3,PRP16,GAT4,DBP6,PPA2,YAP3,TFC7,APC11,DCN1,SIR3,PAC2,MTF1,SSP1,HKR1,FSH3,CBP3,RPI1 GO:0001403 4 invasive growth (sensu Saccharomyces) 32 0.0050 2 0.0220 0.0642379 E DIA4,DIA1 GO:0000096 7,8,6 sulfur amino acid metabolism 32 0.0050 2 0.0220 0.0642379 E MET16,MET2 GO:0051301 4 cell division 123 0.0191 4 0.0440 0.0657481 E MYO1,SLA2,ATS1,HKR1 GO:0044242 6,7 cellular lipid catabolism 5 0.0008 1 0.0110 0.0666466 E SPS19 GO:0006627 11,9,10 mitochondrial protein processing 5 0.0008 1 0.0110 0.0666466 E IMP2 GO:0009086 9,10,8 methionine biosynthesis 5 0.0008 1 0.0110 0.0666466 E MET2 GO:0016042 5,6 lipid catabolism 5 0.0008 1 0.0110 0.0666466 E SPS19 GO:0019541 7 propionate metabolism 5 0.0008 1 0.0110 0.0666466 E PDR12 GO:0019954 3 asexual reproduction 77 0.0119 3 0.0330 0.0713921 E MYO1,SLA2,ATS1 GO:0007114 5,4 cell budding 77 0.0119 3 0.0330 0.0713921 E MYO1,SLA2,ATS1 GO:0048518 3 positive regulation of biological process 78 0.0121 3 0.0330 0.0732232 E FZF1,DCN1,SIR3 GO:0016071 7 mRNA metabolism 185 0.0287 5 0.0549 0.0735849 E MPE1,PRP8,SYF2,SKI3,PRP16 GO:0051179 3 localization 991 0.1535 17 0.1868 0.0741840 E CYT1,MON1,FZF1,PDR12,SLA2,HXT4,COG6,TOM1,IMP2,NAT3,ALP1,TEX1,MIP6,EHD3,RHB1,HOL1,APL6 GO:0006810 4,5 transport 924 0.1432 16 0.1758 0.0754504 E CYT1,MON1,FZF1,PDR12,SLA2,HXT4,COG6,TOM1,IMP2,ALP1,TEX1,MIP6,EHD3,RHB1,HOL1,APL6 GO:0006397 8 mRNA processing 132 0.0205 4 0.0440 0.0772522 E MPE1,PRP8,SYF2,PRP16 GO:0043283 5 biopolymer metabolism 1593 0.2468 25 0.2747 0.0778830 E RAT1,MPE1,PRP8,DSK2,DIA4,PPT2,MSH5,MNT4,TOM1,SYF2,UNG1,HOS1,IMP2,NAT3,DBF4,SKI3,REV1,UBC12,MSE1,PRP16,DBP6,APC11,DCN1,SIR3,HKR1 GO:0045026 4 plasma membrane fusion 6 0.0009 1 0.0110 0.0788598 E FIG2 GO:0009092 8,9 homoserine metabolism 6 0.0009 1 0.0110 0.0788598 E MET2 GO:0031365 9 N-terminal protein amino acid modification 6 0.0009 1 0.0110 0.0788598 E NAT3 GO:0006474 11,9 N-terminal protein amino acid acetylation 6 0.0009 1 0.0110 0.0788598 E NAT3 GO:0015807 7,8,9 L-amino acid transport 6 0.0009 1 0.0110 0.0788598 E RHB1 GO:0018409 10 peptide or protein amino-terminal blocking 6 0.0009 1 0.0110 0.0788598 E NAT3 GO:0006865 6,7,8 amino acid transport 37 0.0057 2 0.0220 0.0804396 E ALP1,RHB1 GO:0030471 4 spindle pole body and microtubule cycle (sensu Fungi) 37 0.0057 2 0.0220 0.0804396 E DSK2,DAD2 GO:0051234 4 establishment of localization 942 0.1460 16 0.1758 0.0805197 E CYT1,MON1,FZF1,PDR12,SLA2,HXT4,COG6,TOM1,IMP2,ALP1,TEX1,MIP6,EHD3,RHB1,HOL1,APL6 GO:0044238 4 primary metabolism 3152 0.4884 45 0.4945 0.0834310 E MET16,RAT1,MPE1,FZF1,PRP8,DSK2,DIA4,MET2,PPT2,MSH5,SPS19,MNT4,MTG1,NAM9,TOM1,SYF2,UNG1,HOS1,DCI1,ATP11,IMP2,NAT3,DBF4,SKI3,REV1,NCR1,UBC12,SRB2,EHD3,MRPL44,MSE1,TOS3,PRP16,GAT4,DBP6,YAP3,TFC7,APC11,DCN1,SIR3,PAC2,MTF1,SSP1,HKR1,CBP3 GO:0044260 5 cellular macromolecule metabolism 1448 0.2244 22 0.2418 0.0905748 E DSK2,DIA4,PPT2,MNT4,MTG1,NAM9,TOM1,HOS1,ATP11,IMP2,NAT3,DBF4,UBC12,MRPL44,MSE1,DBP6,APC11,DCN1,PAC2,SSP1,HKR1,CBP3 GO:0043085 4 positive regulation of enzyme activity 7 0.0011 1 0.0110 0.0907189 E DCN1 GO:0009613 6,5 response to pest, pathogen or parasite 7 0.0011 1 0.0110 0.0907189 E SKI3 GO:0009615 7,6 response to virus 7 0.0011 1 0.0110 0.0907189 E SKI3 GO:0009607 4 response to biotic stimulus 7 0.0011 1 0.0110 0.0907189 E SKI3 GO:0043331 6 response to dsRNA 7 0.0011 1 0.0110 0.0907189 E SKI3 GO:0043207 5 response to external biotic stimulus 7 0.0011 1 0.0110 0.0907189 E SKI3 GO:0043330 7,8 response to exogenous dsRNA 7 0.0011 1 0.0110 0.0907189 E SKI3 GO:0000902 5,4 cellular morphogenesis 144 0.0223 4 0.0440 0.0929948 E MYO1,SLA2,FIG2,HKR1 GO:0009653 3 morphogenesis 144 0.0223 4 0.0440 0.0929948 E MYO1,SLA2,FIG2,HKR1 GO:0044267 6 cellular protein metabolism 1400 0.2169 21 0.2308 0.0945922 E DSK2,DIA4,PPT2,MNT4,MTG1,NAM9,TOM1,HOS1,ATP11,IMP2,NAT3,DBF4,UBC12,MRPL44,MSE1,DBP6,APC11,DCN1,PAC2,SSP1,CBP3 GO:0007067 7 mitosis 146 0.0226 4 0.0440 0.0956339 E TOM1,CHL1,APC11,DAD2 GO:0019538 5 protein metabolism 1424 0.2206 21 0.2308 0.0968898 E DSK2,DIA4,PPT2,MNT4,MTG1,NAM9,TOM1,HOS1,ATP11,IMP2,NAT3,DBF4,UBC12,MRPL44,MSE1,DBP6,APC11,DCN1,PAC2,SSP1,CBP3 GO:0007052 8,10 mitotic spindle organization and biogenesis 42 0.0065 2 0.0220 0.0969754 E APC11,DAD2 GO:0000087 6 M phase of mitotic cell cycle 148 0.0229 4 0.0440 0.0982717 E TOM1,CHL1,APC11,DAD2 GO:0006350 6 transcription 484 0.0750 9 0.0989 0.0988366 E RAT1,FZF1,HOS1,SRB2,GAT4,YAP3,TFC7,SIR3,MTF1 GO:0007051 9 spindle organization and biogenesis 43 0.0067 2 0.0220 0.1002942 E APC11,DAD2 GO:0051274 10,9,8 beta-glucan biosynthesis 8 0.0012 1 0.0110 0.1022314 E HKR1 GO:0001308 8,12,11,7,6 loss of chromatin silencing during replicative cell aging 8 0.0012 1 0.0110 0.1022314 E SIR3 GO:0000393 10,12 spliceosomal conformational changes to generate catalytic conformation 8 0.0012 1 0.0110 0.1022314 E PRP16 GO:0006275 9,8 regulation of DNA replication 8 0.0012 1 0.0110 0.1022314 E DBF4 GO:0043412 6 biopolymer modification 567 0.0879 10 0.1099 0.1030117 E PPT2,MNT4,TOM1,HOS1,IMP2,NAT3,DBF4,UBC12,APC11,DCN1 GO:0007005 6 mitochondrion organization and biogenesis 95 0.0147 3 0.0330 0.1051589 E FZO1,NAT3,PNT1 GO:0009066 7,8 aspartate family amino acid metabolism 45 0.0070 2 0.0220 0.1069251 E MET16,MET2 GO:0000910 5 cytokinesis 97 0.0150 3 0.0330 0.1089365 E MYO1,SLA2,HKR1 GO:0000398 9,11 nuclear mRNA splicing, via spliceosome 97 0.0150 3 0.0330 0.1089365 E PRP8,SYF2,PRP16 GO:0043161 11,12 proteasomal ubiquitin-dependent protein catabolism 46 0.0071 2 0.0220 0.1102330 E DSK2,APC11 GO:0000377 10 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 98 0.0152 3 0.0330 0.1108210 E PRP8,SYF2,PRP16 GO:0006345 11,10,5 loss of chromatin silencing 9 0.0014 1 0.0110 0.1134045 E SIR3 GO:0006374 10,12 nuclear mRNA splicing via U2-type spliceosome 9 0.0014 1 0.0110 0.1134045 E PRP16 GO:0000097 8,9,7 sulfur amino acid biosynthesis 9 0.0014 1 0.0110 0.1134045 E MET2 GO:0006122 9,11,8 mitochondrial electron transport, ubiquinol to cytochrome c 9 0.0014 1 0.0110 0.1134045 E CYT1 GO:0045815 4 positive regulation of gene expression, epigenetic 9 0.0014 1 0.0110 0.1134045 E SIR3 GO:0051273 8,9 beta-glucan metabolism 9 0.0014 1 0.0110 0.1134045 E HKR1 GO:0001304 7,6 progressive alteration of chromatin during replicative cell aging 9 0.0014 1 0.0110 0.1134045 E SIR3 GO:0007129 9 synapsis 9 0.0014 1 0.0110 0.1134045 E HOP2 GO:0006760 6,8,7 folic acid and derivative metabolism 9 0.0014 1 0.0110 0.1134045 E FSH3 GO:0016050 6 vesicle organization and biogenesis 9 0.0014 1 0.0110 0.1134045 E PRM9 GO:0006351 7 transcription, DNA-dependent 441 0.0683 8 0.0879 0.1140773 E RAT1,FZF1,HOS1,SRB2,YAP3,TFC7,SIR3,MTF1 GO:0015837 5,6 amine transport 48 0.0074 2 0.0220 0.1168238 E ALP1,RHB1 GO:0007124 4 pseudohyphal growth 48 0.0074 2 0.0220 0.1168238 E DIA4,DIA1 GO:0030010 7,8,6 establishment of cell polarity 103 0.0160 3 0.0330 0.1201787 E MYO1,SLA2,HKR1 GO:0030468 8,9,7 establishment of cell polarity (sensu Fungi) 103 0.0160 3 0.0330 0.1201787 E MYO1,SLA2,HKR1 GO:0016070 6 RNA metabolism 539 0.0835 9 0.0989 0.1221993 E RAT1,MPE1,PRP8,DIA4,SYF2,SKI3,MSE1,PRP16,DBP6 GO:0046942 6,7 carboxylic acid transport 50 0.0077 2 0.0220 0.1233688 E ALP1,RHB1 GO:0000375 9 RNA splicing, via transesterification reactions 105 0.0163 3 0.0330 0.1238820 E PRP8,SYF2,PRP16 GO:0006791 6 sulfur utilization 10 0.0015 1 0.0110 0.1242454 E MET16 GO:0030846 10 transcription termination from Pol II promoter, RNA polymerase(A) coupled 10 0.0015 1 0.0110 0.1242454 E RAT1 GO:0001301 6,5 progressive alteration of chromatin during cell aging 10 0.0015 1 0.0110 0.1242454 E SIR3 GO:0000103 7 sulfate assimilation 10 0.0015 1 0.0110 0.1242454 E MET16 GO:0007021 10,8 tubulin folding 10 0.0015 1 0.0110 0.1242454 E PAC2 GO:0007163 6,7,5 establishment and/or maintenance of cell polarity 107 0.0166 3 0.0330 0.1275567 E MYO1,SLA2,HKR1 GO:0030467 7,8,6 establishment and/or maintenance of cell polarity (sensu Fungi) 107 0.0166 3 0.0330 0.1275567 E MYO1,SLA2,HKR1 GO:0006913 8,6,7 nucleocytoplasmic transport 109 0.0169 3 0.0330 0.1311989 E TOM1,TEX1,MIP6 GO:0045132 8,5 meiotic chromosome segregation 11 0.0017 1 0.0110 0.1347612 E CSM4 GO:0006384 9 transcription initiation from RNA polymerase III promoter 11 0.0017 1 0.0110 0.1347612 E TFC7 GO:0040007 2 growth 113 0.0175 3 0.0330 0.1383719 E DIA4,ATS1,DIA1 GO:0000070 8,6 mitotic sister chromatid segregation 55 0.0085 2 0.0220 0.1394428 E CHL1,APC11 GO:0000819 5 sister chromatid segregation 55 0.0085 2 0.0220 0.1394428 E CHL1,APC11 GO:0006520 6,7 amino acid metabolism 182 0.0282 4 0.0440 0.1410346 E MET16,DIA4,MET2,MSE1 GO:0007127 8 meiosis I 56 0.0087 2 0.0220 0.1425961 E HOP2,MSH5 GO:0051641 5,4 cellular localization 521 0.0807 8 0.0879 0.1427339 E MON1,COG6,TOM1,IMP2,NAT3,TEX1,MIP6,APL6 GO:0008054 6,12,13 cyclin catabolism 12 0.0019 1 0.0110 0.1449586 E APC11 GO:0007103 9,6 spindle pole body duplication in nuclear envelope 12 0.0019 1 0.0110 0.1449586 E DSK2 GO:0000741 7 karyogamy 12 0.0019 1 0.0110 0.1449586 E PRM3 GO:0006790 5 sulfur metabolism 57 0.0088 2 0.0220 0.1457257 E MET16,MET2 GO:0050896 3 response to stimulus 549 0.0851 8 0.0879 0.1465192 E WAR1,MYO1,FIG2,UNG1,SKI3,REV1,SIR3,RAD61 GO:0006396 7 RNA processing 346 0.0536 6 0.0659 0.1472956 E RAT1,MPE1,PRP8,SYF2,PRP16,DBP6 GO:0045893 9 positive regulation of transcription, DNA-dependent 59 0.0091 2 0.0220 0.1519088 E FZF1,SIR3 GO:0051300 7 spindle pole body organization and biogenesis 13 0.0020 1 0.0110 0.1548446 E DSK2 GO:0031110 10,6 regulation of microtubule polymerization or depolymerization 13 0.0020 1 0.0110 0.1548446 E DAD2 GO:0006476 8 protein amino acid deacetylation 13 0.0020 1 0.0110 0.1548446 E HOS1 GO:0007007 7,8 inner mitochondrial membrane organization and biogenesis 13 0.0020 1 0.0110 0.1548446 E PNT1 GO:0031023 6 microtubule organizing center organization and biogenesis 13 0.0020 1 0.0110 0.1548446 E DSK2 GO:0030474 8,5 spindle pole body duplication 13 0.0020 1 0.0110 0.1548446 E DSK2 GO:0046907 7,5,6 intracellular transport 488 0.0756 7 0.0769 0.1560213 E MON1,COG6,TOM1,IMP2,TEX1,MIP6,APL6 GO:0006519 5 amino acid and derivative metabolism 197 0.0305 4 0.0440 0.1573661 E MET16,DIA4,MET2,MSE1 GO:0016192 5,6 vesicle-mediated transport 282 0.0437 5 0.0549 0.1599272 E MON1,SLA2,COG6,EHD3,APL6 GO:0008380 8 RNA splicing 126 0.0195 3 0.0330 0.1603815 E PRP8,SYF2,PRP16 GO:0006406 11,9,10,8 mRNA export from nucleus 62 0.0096 2 0.0220 0.1609763 E TEX1,MIP6 GO:0051028 8,7,9 mRNA transport 62 0.0096 2 0.0220 0.1609763 E TEX1,MIP6 GO:0031109 9 microtubule polymerization or depolymerization 14 0.0022 1 0.0110 0.1644256 E DAD2 GO:0006779 7 porphyrin biosynthesis 14 0.0022 1 0.0110 0.1644256 E HEM4 GO:0006783 8,7 heme biosynthesis 14 0.0022 1 0.0110 0.1644256 E HEM4 GO:0046148 6 pigment biosynthesis 14 0.0022 1 0.0110 0.1644256 E HEM4 GO:0048278 6,7 vesicle docking 14 0.0022 1 0.0110 0.1644256 E MON1 GO:0042255 7,8 ribosome assembly 64 0.0099 2 0.0220 0.1668710 E MTG1,DBP6 GO:0044255 5,6 cellular lipid metabolism 208 0.0322 4 0.0440 0.1679046 E SPS19,DCI1,NCR1,EHD3 GO:0045941 8 positive regulation of transcription 65 0.0101 2 0.0220 0.1697706 E FZF1,SIR3 GO:0009628 4 response to abiotic stimulus 301 0.0466 5 0.0549 0.1700339 E WAR1,MYO1,FIG2,SKI3,RAD61 GO:0045935 7 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 66 0.0102 2 0.0220 0.1726371 E FZF1,SIR3 GO:0044272 6 sulfur compound biosynthesis 15 0.0023 1 0.0110 0.1737083 E MET2 GO:0006369 9 transcription termination from RNA polymerase II promoter 15 0.0023 1 0.0110 0.1737083 E RAT1 GO:0031145 12,13 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism 15 0.0023 1 0.0110 0.1737083 E APC11 GO:0042168 7,6 heme metabolism 15 0.0023 1 0.0110 0.1737083 E HEM4 GO:0006379 9 mRNA cleavage 15 0.0023 1 0.0110 0.1737083 E MPE1 GO:0051278 9,8,7 cell wall polysaccharide biosynthesis (sensu Fungi) 15 0.0023 1 0.0110 0.1737083 E HKR1 GO:0042440 5 pigment metabolism 15 0.0023 1 0.0110 0.1737083 E HEM4 GO:0006778 6 porphyrin metabolism 15 0.0023 1 0.0110 0.1737083 E HEM4 GO:0007091 8 mitotic metaphase/anaphase transition 15 0.0023 1 0.0110 0.1737083 E APC11 GO:0009308 5 amine metabolism 218 0.0338 4 0.0440 0.1763008 E MET16,DIA4,MET2,MSE1 GO:0031325 6 positive regulation of cellular metabolism 68 0.0105 2 0.0220 0.1782678 E FZF1,SIR3 GO:0009893 5 positive regulation of metabolism 68 0.0105 2 0.0220 0.1782678 E FZF1,SIR3 GO:0006629 5 lipid metabolism 222 0.0344 4 0.0440 0.1793269 E SPS19,DCI1,NCR1,EHD3 GO:0006897 6,7 endocytosis 69 0.0107 2 0.0220 0.1810306 E SLA2,EHD3 GO:0006365 9 35S primary transcript processing 69 0.0107 2 0.0220 0.1810306 E RAT1,DBP6 GO:0045229 5 external encapsulating structure organization and biogenesis 141 0.0218 3 0.0330 0.1825929 E SLA2,SPS22,HKR1 GO:0007047 6 cell wall organization and biogenesis 141 0.0218 3 0.0330 0.1825929 E SLA2,SPS22,HKR1 GO:0000753 7,8,6 cellular morphogenesis during conjugation with cellular fusion 16 0.0025 1 0.0110 0.1826990 E FIG2 GO:0015698 7,8 inorganic anion transport 16 0.0025 1 0.0110 0.1826990 E FZF1 GO:0007265 7 Ras protein signal transduction 16 0.0025 1 0.0110 0.1826990 E RPI1 GO:0006493 10,9 protein amino acid O-linked glycosylation 16 0.0025 1 0.0110 0.1826990 E MNT4 GO:0051231 10 spindle elongation 16 0.0025 1 0.0110 0.1826990 E APC11 GO:0000022 9,11 mitotic spindle elongation 16 0.0025 1 0.0110 0.1826990 E APC11 GO:0000278 5 mitotic cell cycle 231 0.0358 4 0.0440 0.1854206 E TOM1,CHL1,APC11,DAD2 GO:0046483 5 heterocycle metabolism 71 0.0110 2 0.0220 0.1864477 E HEM4,FSH3 GO:0043119 4 positive regulation of physiological process 71 0.0110 2 0.0220 0.1864477 E FZF1,SIR3 GO:0051242 5 positive regulation of cellular physiological process 71 0.0110 2 0.0220 0.1864477 E FZF1,SIR3 GO:0048522 4 positive regulation of cellular process 71 0.0110 2 0.0220 0.1864477 E FZF1,SIR3 GO:0006807 4 nitrogen compound metabolism 236 0.0366 4 0.0440 0.1883725 E MET16,DIA4,MET2,MSE1 GO:0006405 10,8,9,7 RNA export from nucleus 72 0.0112 2 0.0220 0.1891008 E TEX1,MIP6 GO:0050657 6,7 nucleic acid transport 72 0.0112 2 0.0220 0.1891008 E TEX1,MIP6 GO:0051236 5 establishment of RNA localization 72 0.0112 2 0.0220 0.1891008 E TEX1,MIP6 GO:0050658 7,6,8 RNA transport 72 0.0112 2 0.0220 0.1891008 E TEX1,MIP6 GO:0018193 8 peptidyl-amino acid modification 17 0.0026 1 0.0110 0.1914040 E NAT3 GO:0006353 8 transcription termination 17 0.0026 1 0.0110 0.1914040 E RAT1 GO:0006820 6,7 anion transport 17 0.0026 1 0.0110 0.1914040 E FZF1 GO:0006281 7,6 DNA repair 150 0.0232 3 0.0330 0.1939806 E UNG1,REV1,SIR3 GO:0006766 5 vitamin metabolism 74 0.0115 2 0.0220 0.1942934 E FSH3,RPI1 GO:0006767 6 water-soluble vitamin metabolism 74 0.0115 2 0.0220 0.1942934 E FSH3,RPI1 GO:0006896 10,9,8,7 Golgi to vacuole transport 18 0.0028 1 0.0110 0.1998295 E APL6 GO:0000767 6,5 cellular morphogenesis during conjugation 18 0.0028 1 0.0110 0.1998295 E FIG2 GO:0006378 10 mRNA polyadenylylation 18 0.0028 1 0.0110 0.1998295 E MPE1 GO:0009067 8,9 aspartate family amino acid biosynthesis 18 0.0028 1 0.0110 0.1998295 E MET2 GO:0019748 4 secondary metabolism 18 0.0028 1 0.0110 0.1998295 E HEM4 GO:0006366 8 transcription from RNA polymerase II promoter 277 0.0429 4 0.0440 0.2010139 E RAT1,FZF1,SRB2,YAP3 GO:0007006 6,7 mitochondrial membrane organization and biogenesis 19 0.0029 1 0.0110 0.2079815 E PNT1 GO:0009250 9,8,7 glucan biosynthesis 19 0.0029 1 0.0110 0.2079815 E HKR1 GO:0006081 5 aldehyde metabolism 19 0.0029 1 0.0110 0.2079815 E AAD6 GO:0006303 9,8 double-strand break repair via nonhomologous end-joining 19 0.0029 1 0.0110 0.2079815 E SIR3 GO:0007064 9,6,7 mitotic sister chromatid cohesion 19 0.0029 1 0.0110 0.2079815 E CHL1 GO:0009228 8,9 thiamin biosynthesis 19 0.0029 1 0.0110 0.2079815 E RPI1 GO:0006261 8 DNA-dependent DNA replication 80 0.0124 2 0.0220 0.2089296 E DBF4,REV1 GO:0015931 5,6 nucleobase, nucleoside, nucleotide and nucleic acid transport 80 0.0124 2 0.0220 0.2089296 E TEX1,MIP6 GO:0006403 4 RNA localization 83 0.0129 2 0.0220 0.2157008 E TEX1,MIP6 GO:0030433 10,12,11,13 ER-associated protein catabolism 20 0.0031 1 0.0110 0.2158660 E DSK2 GO:0042724 8 thiamin and derivative biosynthesis 20 0.0031 1 0.0110 0.2158660 E RPI1 GO:0042546 7,6 cell wall biosynthesis 20 0.0031 1 0.0110 0.2158660 E HKR1 GO:0009272 8,7 cell wall biosynthesis (sensu Fungi) 20 0.0031 1 0.0110 0.2158660 E HKR1 GO:0006772 8 thiamin metabolism 20 0.0031 1 0.0110 0.2158660 E RPI1 GO:0009060 8 aerobic respiration 84 0.0130 2 0.0220 0.2178750 E DIA4,PPA2 GO:0006974 5 response to DNA damage stimulus 177 0.0274 3 0.0330 0.2185543 E UNG1,REV1,SIR3 GO:0009719 4 response to endogenous stimulus 183 0.0284 3 0.0330 0.2220403 E UNG1,REV1,SIR3 GO:0051168 9,7,8 nuclear export 86 0.0133 2 0.0220 0.2220983 E TEX1,MIP6 GO:0006891 9,7,6,8 intra-Golgi transport 21 0.0033 1 0.0110 0.2234887 E COG6 GO:0051052 7 regulation of DNA metabolism 21 0.0033 1 0.0110 0.2234887 E DBF4 GO:0031505 7 cell wall organization and biogenesis (sensu Fungi) 21 0.0033 1 0.0110 0.2234887 E HKR1 GO:0015749 6,7 monosaccharide transport 21 0.0033 1 0.0110 0.2234887 E HXT4 GO:0008645 7,8 hexose transport 21 0.0033 1 0.0110 0.2234887 E HXT4 GO:0030447 3 filamentous growth 87 0.0135 2 0.0220 0.2241470 E DIA4,DIA1 GO:0045333 7 cellular respiration 89 0.0138 2 0.0220 0.2281182 E DIA4,PPA2 GO:0045045 5,6 secretory pathway 202 0.0313 3 0.0330 0.2285734 E SLA2,COG6,APL6 GO:0046903 5 secretion 209 0.0324 3 0.0330 0.2293576 E SLA2,COG6,APL6 GO:0051128 5 regulation of cell organization and biogenesis 22 0.0034 1 0.0110 0.2308555 E DAD2 GO:0042723 7 thiamin and derivative metabolism 22 0.0034 1 0.0110 0.2308555 E RPI1 GO:0007120 6,8,10,11,9,5 axial bud site selection 22 0.0034 1 0.0110 0.2308555 E MYO1 GO:0006515 9,10 misfolded or incompletely synthesized protein catabolism 22 0.0034 1 0.0110 0.2308555 E DSK2 GO:0009069 7,8 serine family amino acid metabolism 22 0.0034 1 0.0110 0.2308555 E MET2 GO:0030472 9,11,5 mitotic spindle organization and biogenesis in nucleus 24 0.0037 1 0.0110 0.2448433 E DAD2 GO:0051169 8,6,7 nuclear transport 103 0.0160 2 0.0220 0.2512001 E TEX1,MIP6 GO:0006399 7 tRNA metabolism 103 0.0160 2 0.0220 0.2512001 E DIA4,MSE1 GO:0006260 7 DNA replication 103 0.0160 2 0.0220 0.2512001 E DBF4,REV1 GO:0050790 3 regulation of enzyme activity 25 0.0039 1 0.0110 0.2514753 E DCN1 GO:0051646 6,5 mitochondrion localization 25 0.0039 1 0.0110 0.2514753 E NAT3 GO:0000001 8,7 mitochondrion inheritance 25 0.0039 1 0.0110 0.2514753 E NAT3 GO:0042775 8,10,7 ATP synthesis coupled electron transport (sensu Eukaryota) 25 0.0039 1 0.0110 0.2514753 E CYT1 GO:0048311 7,6 mitochondrion distribution 25 0.0039 1 0.0110 0.2514753 E NAT3 GO:0006270 9 DNA replication initiation 25 0.0039 1 0.0110 0.2514753 E DBF4 GO:0042773 7,9,6 ATP synthesis coupled electron transport 25 0.0039 1 0.0110 0.2514753 E CYT1 GO:0009605 4 response to external stimulus 27 0.0042 1 0.0110 0.2640418 E SKI3 GO:0006511 10,11 ubiquitin-dependent protein catabolism 121 0.0187 2 0.0220 0.2692013 E DSK2,APC11 GO:0019941 9,10 modification-dependent protein catabolism 121 0.0187 2 0.0220 0.2692013 E DSK2,APC11 GO:0000271 8,7,6 polysaccharide biosynthesis 28 0.0043 1 0.0110 0.2699867 E HKR1 GO:0043284 7,5,6 biopolymer biosynthesis 28 0.0043 1 0.0110 0.2699867 E HKR1 GO:0000726 8,7 non-recombinational repair 28 0.0043 1 0.0110 0.2699867 E SIR3 GO:0044257 7,8 cellular protein catabolism 123 0.0191 2 0.0220 0.2704465 E DSK2,APC11 GO:0051603 8,9 proteolysis during cellular protein catabolism 123 0.0191 2 0.0220 0.2704465 E DSK2,APC11 GO:0048193 8,6,7 Golgi vesicle transport 141 0.0218 2 0.0220 0.2756384 E COG6,APL6 GO:0006665 7,8 sphingolipid metabolism 29 0.0045 1 0.0110 0.2757127 E NCR1 GO:0007117 6,4,5 budding cell bud growth 30 0.0046 1 0.0110 0.2812248 E ATS1 GO:0048590 3 non-developmental growth 30 0.0046 1 0.0110 0.2812248 E ATS1 GO:0006118 6,5 electron transport 31 0.0048 1 0.0110 0.2865276 E CYT1 GO:0007121 6,8,10,11,9,5 bipolar bud site selection 32 0.0050 1 0.0110 0.2916261 E SLA2 GO:0030004 7 monovalent inorganic cation homeostasis 32 0.0050 1 0.0110 0.2916261 E NHA1 GO:0016044 5 membrane organization and biogenesis 32 0.0050 1 0.0110 0.2916261 E PNT1 GO:0016485 8 protein processing 32 0.0050 1 0.0110 0.2916261 E IMP2 GO:0007020 9 microtubule nucleation 33 0.0051 1 0.0110 0.2965247 E PAC2 GO:0001302 6,5 replicative cell aging 33 0.0051 1 0.0110 0.2965247 E SIR3 GO:0008643 5,6 carbohydrate transport 34 0.0053 1 0.0110 0.3012281 E HXT4 GO:0006887 6,7 exocytosis 36 0.0056 1 0.0110 0.3100670 E SLA2 GO:0006914 4 autophagy 36 0.0056 1 0.0110 0.3100670 E MON1 GO:0048308 6 organelle inheritance 38 0.0059 1 0.0110 0.3181773 E NAT3 GO:0009110 6 vitamin biosynthesis 38 0.0059 1 0.0110 0.3181773 E RPI1 GO:0006383 8 transcription from RNA polymerase III promoter 38 0.0059 1 0.0110 0.3181773 E TFC7 GO:0042364 7 water-soluble vitamin biosynthesis 38 0.0059 1 0.0110 0.3181773 E RPI1 GO:0006473 8 protein amino acid acetylation 38 0.0059 1 0.0110 0.3181773 E NAT3 GO:0007131 9,8 meiotic recombination 39 0.0060 1 0.0110 0.3219697 E MSH5 GO:0006073 7,8 glucan metabolism 39 0.0060 1 0.0110 0.3219697 E HKR1 GO:0000027 9,10 ribosomal large subunit assembly and maintenance 39 0.0060 1 0.0110 0.3219697 E DBP6 GO:0006302 8,7 double-strand break repair 41 0.0064 1 0.0110 0.3290494 E SIR3 GO:0007569 5,4 cell aging 41 0.0064 1 0.0110 0.3290494 E SIR3 GO:0007568 3,4 aging 42 0.0065 1 0.0110 0.3323444 E SIR3 GO:0006752 7 group transfer coenzyme metabolism 44 0.0068 1 0.0110 0.3384642 E FSH3 GO:0008219 4 cell death 46 0.0071 1 0.0110 0.3439815 E SIR3 GO:0006119 6,8 oxidative phosphorylation 46 0.0071 1 0.0110 0.3439815 E CYT1 GO:0016265 3 death 47 0.0073 1 0.0110 0.3465231 E SIR3 GO:0006626 10,8,9 protein targeting to mitochondrion 47 0.0073 1 0.0110 0.3465231 E IMP2 GO:0007034 8,6,7 vacuolar transport 48 0.0074 1 0.0110 0.3489247 E APL6 GO:0045944 10 positive regulation of transcription from RNA polymerase II promoter 48 0.0074 1 0.0110 0.3489247 E FZF1 GO:0051640 4 organelle localization 49 0.0076 1 0.0110 0.3511897 E NAT3 GO:0006892 9,7,6,8 post-Golgi transport 51 0.0079 1 0.0110 0.3553230 E APL6 GO:0042257 8,9 ribosomal subunit assembly 52 0.0081 1 0.0110 0.3571978 E DBP6 GO:0044264 6,7 cellular polysaccharide metabolism 53 0.0082 1 0.0110 0.3589489 E HKR1 GO:0005976 6 polysaccharide metabolism 53 0.0082 1 0.0110 0.3589489 E HKR1 GO:0000749 7,5 response to pheromone during conjugation with cellular fusion 53 0.0082 1 0.0110 0.3589489 E FIG2 GO:0006402 8 mRNA catabolism 55 0.0085 1 0.0110 0.3620922 E SKI3 GO:0006352 8 transcription initiation 55 0.0085 1 0.0110 0.3620922 E TFC7 GO:0007264 6 small GTPase mediated signal transduction 55 0.0085 1 0.0110 0.3620922 E RPI1 GO:0006725 5 aromatic compound metabolism 57 0.0088 1 0.0110 0.3647768 E FSH3 GO:0006944 3 membrane fusion 58 0.0090 1 0.0110 0.3659543 E FIG2 GO:0006970 5 response to osmotic stress 59 0.0091 1 0.0110 0.3670256 E MYO1 GO:0006623 10,8,9 protein targeting to vacuole 59 0.0091 1 0.0110 0.3670256 E MON1 GO:0007015 9 actin filament organization 63 0.0098 1 0.0110 0.3703031 E SLA2 GO:0016051 7,6 carbohydrate biosynthesis 63 0.0098 1 0.0110 0.3703031 E HKR1 GO:0006401 7 RNA catabolism 64 0.0099 1 0.0110 0.3708834 E SKI3 GO:0006006 8,9 glucose metabolism 65 0.0101 1 0.0110 0.3713731 E TOS3 GO:0043413 7 biopolymer glycosylation 67 0.0104 1 0.0110 0.3720903 E MNT4 GO:0006486 9,8 protein amino acid glycosylation 67 0.0104 1 0.0110 0.3720903 E MNT4 GO:0006457 7 protein folding 67 0.0104 1 0.0110 0.3720903 E PAC2 GO:0008150 1 biological_process 6454 1.0000 91 1.0000 1.0000000 D HOP2,MET16,CYT1,PAU5,RAT1,AAD6,WAR1,PFS1,MPE1,MON1,MYO1,FZF1,SPO22,PRP8,PDR12,DSK2,SLA2,SPS22,DIA4,MET2,PPT2,MSH5,SPS19,HXT4,MNT4,FIG2,COG6,MTG1,FZO1,NAM9,TOM1,PRM3,NKP2,SYF2,UNG1,HOS1,HEM4,DCI1,ATP11,IMP2,FRE7,NAT3,ALP1,CHL1,EAF6,PNT1,DBF4,TEX1,ATS1,SKI3,REV1,NCR1,MIP6,UBC12,SRB2,EHD3,MRPL44,MSE1,TOS3,PRP16,GAT4,DBP6,PPA2,YTA6,NHA1,YAP3,TFC7,RHB1,APC11,SPO7,DCN1,OSW2,REC8,DIA1,SIR3,HNT3,PAC2,RAD61,HOL1,PRM9,APL6,MTF1,PAU3,CSM4,FMP51,DAD2,SSP1,HKR1,FSH3,CBP3,RPI1 GO:0051188 6 cofactor biosynthesis 71 0.0110 1 0.0110 0.3725402 D HEM4 GO:0009101 8,7 glycoprotein biosynthesis 72 0.0112 1 0.0110 0.3724605 D MNT4 GO:0009100 7 glycoprotein metabolism 73 0.0113 1 0.0110 0.3723081 D MNT4 GO:0019236 6 response to pheromone 73 0.0113 1 0.0110 0.3723081 D FIG2 GO:0031507 11 heterochromatin formation 79 0.0122 1 0.0110 0.3699796 D SIR3 GO:0045814 4 negative regulation of gene expression, epigenetic 79 0.0122 1 0.0110 0.3699796 D SIR3 GO:0016458 6 gene silencing 79 0.0122 1 0.0110 0.3699796 D SIR3 GO:0006342 12,7,10,5 chromatin silencing 79 0.0122 1 0.0110 0.3699796 D SIR3 GO:0040029 3 regulation of gene expression, epigenetic 84 0.0130 1 0.0110 0.3663917 D SIR3 GO:0031497 10 chromatin assembly 84 0.0130 1 0.0110 0.3663917 D SIR3 GO:0019318 7,8 hexose metabolism 85 0.0132 1 0.0110 0.3655153 D TOS3 GO:0030003 6 cation homeostasis 89 0.0138 1 0.0110 0.3615328 D NHA1 GO:0006468 8 protein amino acid phosphorylation 91 0.0141 1 0.0110 0.3592764 D DBF4 GO:0005996 6,7 monosaccharide metabolism 92 0.0143 1 0.0110 0.3580870 D TOS3 GO:0006873 5 cell ion homeostasis 98 0.0152 1 0.0110 0.3501760 D NHA1 GO:0008652 7,8 amino acid biosynthesis 99 0.0153 1 0.0110 0.3487402 D MET2 GO:0006333 9 chromatin assembly or disassembly 100 0.0155 1 0.0110 0.3472740 D SIR3 GO:0030036 8 actin cytoskeleton organization and biogenesis 100 0.0155 1 0.0110 0.3472740 D SLA2 GO:0050801 4 ion homeostasis 102 0.0158 1 0.0110 0.3442553 D NHA1 GO:0030029 7 actin filament-based process 104 0.0161 1 0.0110 0.3411284 D SLA2 GO:0019953 3 sexual reproduction 105 0.0163 1 0.0110 0.3395271 D FIG2 GO:0000747 6,4 conjugation with cellular fusion 105 0.0163 1 0.0110 0.3395271 D FIG2 GO:0000746 5 conjugation 105 0.0163 1 0.0110 0.3395271 D FIG2 GO:0006643 6,7 membrane lipid metabolism 106 0.0164 1 0.0110 0.3379019 D NCR1 GO:0007242 5 intracellular signaling cascade 107 0.0166 1 0.0110 0.3362538 D RPI1 GO:0006811 5,6 ion transport 107 0.0166 1 0.0110 0.3362538 D FZF1 GO:0009309 6,7 amine biosynthesis 108 0.0167 1 0.0110 0.3345838 D MET2 GO:0019725 4 cell homeostasis 108 0.0167 1 0.0110 0.3345838 D NHA1 GO:0044271 6,5 nitrogen compound biosynthesis 108 0.0167 1 0.0110 0.3345838 D MET2 GO:0042592 3 homeostasis 114 0.0177 1 0.0110 0.3241539 D NHA1 GO:0006732 6 coenzyme metabolism 119 0.0184 1 0.0110 0.3150194 D FSH3 GO:0045892 9 negative regulation of transcription, DNA-dependent 124 0.0192 1 0.0110 0.3055844 D SIR3 GO:0016481 8 negative regulation of transcription 128 0.0198 1 0.0110 0.2978771 D SIR3 GO:0006338 10 chromatin remodeling 132 0.0205 1 0.0110 0.2900700 D SIR3 GO:0045934 7 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 138 0.0214 1 0.0110 0.2782472 D SIR3 GO:0016310 7 phosphorylation 143 0.0222 2 0.0220 0.2756028 D CYT1,DBF4 GO:0030163 6,7 protein catabolism 145 0.0225 2 0.0220 0.2754561 D DSK2,APC11 GO:0051186 5 cofactor metabolism 148 0.0229 2 0.0220 0.2750347 D HEM4,FSH3 GO:0000074 5 regulation of progression through cell cycle 140 0.0217 1 0.0110 0.2742917 D APC11 GO:0006508 7 proteolysis 157 0.0243 2 0.0220 0.2724202 D DSK2,APC11 GO:0043285 5,6 biopolymer catabolism 157 0.0243 2 0.0220 0.2724202 D DSK2,APC11 GO:0006364 8 rRNA processing 176 0.0273 2 0.0220 0.2612995 D RAT1,DBP6 GO:0006357 9 regulation of transcription from RNA polymerase II promoter 181 0.0280 2 0.0220 0.2573504 D FZF1,YAP3 GO:0031324 6 negative regulation of cellular metabolism 150 0.0232 1 0.0110 0.2545547 D SIR3 GO:0006793 5 phosphorus metabolism 188 0.0291 2 0.0220 0.2512533 D CYT1,DBF4 GO:0006796 6 phosphate metabolism 188 0.0291 2 0.0220 0.2512533 D CYT1,DBF4 GO:0015980 6 energy derivation by oxidation of organic compounds 194 0.0301 2 0.0220 0.2455724 D DIA4,PPA2 GO:0006066 5 alcohol metabolism 157 0.0243 1 0.0110 0.2409095 D TOS3 GO:0009892 5 negative regulation of metabolism 157 0.0243 1 0.0110 0.2409095 D SIR3 GO:0044262 6 cellular carbohydrate metabolism 201 0.0311 2 0.0220 0.2385031 D TOS3,HKR1 GO:0006325 8 establishment and/or maintenance of chromatin architecture 205 0.0318 2 0.0220 0.2342841 D HOS1,SIR3 GO:0006323 7 DNA packaging 205 0.0318 2 0.0220 0.2342841 D HOS1,SIR3 GO:0042221 5 response to chemical stimulus 220 0.0341 3 0.0330 0.2289842 D WAR1,FIG2,SKI3 GO:0006091 5 generation of precursor metabolites and energy 224 0.0347 3 0.0330 0.2283942 D CYT1,DIA4,PPA2 GO:0007046 7 ribosome biogenesis 214 0.0332 2 0.0220 0.2244128 D RAT1,DBP6 GO:0007165 4 signal transduction 167 0.0259 1 0.0110 0.2218739 D RPI1 GO:0005975 5 carbohydrate metabolism 219 0.0339 2 0.0220 0.2187512 D TOS3,HKR1 GO:0007028 5 cytoplasm organization and biogenesis 253 0.0392 3 0.0330 0.2179709 D RAT1,MTG1,DBP6 GO:0042254 6 ribosome biogenesis and assembly 253 0.0392 3 0.0330 0.2179709 D RAT1,MTG1,DBP6 GO:0006605 9,7,8 protein targeting 221 0.0342 2 0.0220 0.2164592 D MON1,IMP2 GO:0048523 4 negative regulation of cellular process 170 0.0263 1 0.0110 0.2162966 D SIR3 GO:0051243 5 negative regulation of cellular physiological process 170 0.0263 1 0.0110 0.2162966 D SIR3 GO:0044265 6 cellular macromolecule catabolism 258 0.0400 3 0.0330 0.2152533 D DSK2,SKI3,APC11 GO:0043118 4 negative regulation of physiological process 172 0.0267 1 0.0110 0.2126172 D SIR3 GO:0048519 3 negative regulation of biological process 178 0.0276 1 0.0110 0.2017776 D SIR3 GO:0009057 5 macromolecule catabolism 280 0.0434 3 0.0330 0.2009360 D DSK2,SKI3,APC11 GO:0006355 8 regulation of transcription, DNA-dependent 305 0.0473 4 0.0440 0.1988418 D FZF1,HOS1,YAP3,SIR3 GO:0016568 9 chromatin modification 181 0.0280 1 0.0110 0.1964759 D SIR3 GO:0006886 8,6,7 intracellular protein transport 239 0.0370 2 0.0220 0.1954136 D MON1,IMP2 GO:0045449 7 regulation of transcription 324 0.0502 4 0.0440 0.1933022 D FZF1,HOS1,YAP3,SIR3 GO:0007001 7 chromosome organization and biogenesis (sensu Eukaryota) 243 0.0377 2 0.0220 0.1906948 D HOS1,SIR3 GO:0015031 5,6 protein transport 245 0.0380 2 0.0220 0.1883370 D MON1,IMP2 GO:0044248 5 cellular catabolism 347 0.0538 4 0.0440 0.1831772 D DSK2,SPS19,SKI3,APC11 GO:0006310 7 DNA recombination 189 0.0293 1 0.0110 0.1827494 D MSH5 GO:0019219 6 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism 355 0.0550 5 0.0549 0.1817700 D FZF1,HOS1,DBF4,YAP3,SIR3 GO:0016072 7 rRNA metabolism 254 0.0394 2 0.0220 0.1777727 D RAT1,DBP6 GO:0045184 5 establishment of protein localization 255 0.0395 2 0.0220 0.1766060 D MON1,IMP2 GO:0051276 6 chromosome organization and biogenesis 255 0.0395 2 0.0220 0.1766060 D HOS1,SIR3 GO:0006950 4 response to stress 395 0.0612 5 0.0549 0.1758409 D MYO1,UNG1,SKI3,REV1,SIR3 GO:0031323 5 regulation of cellular metabolism 403 0.0624 5 0.0549 0.1734535 D FZF1,HOS1,DBF4,YAP3,SIR3 GO:0009056 4 catabolism 369 0.0572 4 0.0440 0.1709150 D DSK2,SPS19,SKI3,APC11 GO:0007154 3 cell communication 199 0.0308 1 0.0110 0.1664795 D RPI1 GO:0019222 4 regulation of metabolism 429 0.0665 5 0.0549 0.1635425 D FZF1,HOS1,DBF4,YAP3,SIR3 GO:0051649 6,5 establishment of cellular localization 498 0.0772 7 0.0769 0.1561708 D MON1,COG6,TOM1,IMP2,TEX1,MIP6,APL6 GO:0051244 4 regulation of cellular physiological process 566 0.0877 7 0.0769 0.1455680 D FZF1,HOS1,DBF4,YAP3,APC11,SIR3,DAD2 GO:0050789 2 regulation of biological process 597 0.0925 8 0.0879 0.1454214 D FZF1,HOS1,DBF4,YAP3,APC11,DCN1,SIR3,DAD2 GO:0050794 3 regulation of cellular process 568 0.0880 7 0.0769 0.1449988 D FZF1,HOS1,DBF4,YAP3,APC11,SIR3,DAD2 GO:0008104 4 protein localization 285 0.0442 2 0.0220 0.1428685 D MON1,IMP2 GO:0050791 3 regulation of physiological process 584 0.0905 7 0.0769 0.1400395 D FZF1,HOS1,DBF4,YAP3,APC11,SIR3,DAD2 GO:0006259 6 DNA metabolism 555 0.0860 6 0.0659 0.1295121 D MSH5,UNG1,HOS1,DBF4,REV1,SIR3 GO:0006139 5 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 1500 0.2324 21 0.2308 0.0994702 D RAT1,MPE1,FZF1,PRP8,DIA4,MSH5,SYF2,UNG1,HOS1,DBF4,SKI3,REV1,SRB2,MSE1,PRP16,GAT4,DBP6,YAP3,TFC7,SIR3,MTF1 GO:0043170 4 macromolecule metabolism 2511 0.3891 33 0.3626 0.0761651 D RAT1,MPE1,PRP8,DSK2,DIA4,PPT2,MSH5,MNT4,MTG1,NAM9,TOM1,SYF2,UNG1,HOS1,ATP11,IMP2,NAT3,DBF4,SKI3,REV1,UBC12,MRPL44,MSE1,TOS3,PRP16,DBP6,APC11,DCN1,SIR3,PAC2,SSP1,HKR1,CBP3 GO:0043037 8,7 translation 415 0.0643 2 0.0220 0.0449368 D DIA4,MSE1 GO:0009059 6,5 macromolecule biosynthesis 844 0.1308 7 0.0769 0.0403467 D DIA4,MNT4,MTG1,NAM9,MRPL44,MSE1,HKR1 GO:0006412 7,6 protein biosynthesis 783 0.1213 6 0.0659 0.0352205 D DIA4,MNT4,MTG1,NAM9,MRPL44,MSE1 GO:0044249 5 cellular biosynthesis 1105 0.1712 10 0.1099 0.0340403 D DIA4,MET2,MNT4,MTG1,NAM9,HEM4,MRPL44,MSE1,HKR1,RPI1 GO:0009058 4 biosynthesis 1184 0.1835 10 0.1099 0.0202148 D DIA4,MET2,MNT4,MTG1,NAM9,HEM4,MRPL44,MSE1,HKR1,RPI1 GO:0000004 2 biological process unknown 1639 0.2540 9 0.0989 0.0001175 D PAU5,NKP2,FRE7,EAF6,YTA6,HNT3,PAU3,FMP51,FSH3